General description

MUC5AC is a high molecular weight glycoprotein classified as a secreted mucin produced by epithelial cells. MUC5AC is preferentially expressed in non-neoplastic gastric tissue and benign respiratory tract tissue. During neoplastic transformation, mucin expression may be altered within these tissues leading to particular patterns of expression. Cytoplasmic expression of MUC5AC can be seen in adenocarcinomas of the gastrointestinal tract, particularly those of the esophagus and stomach, as well as the pancreatobiliary tract including cholangiocarcinomas. Other tumors expressing MUC5AC include carcinomas of theendometrium and lung. MUC5AC may also be seen in Paget's disease.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

MUC5AC Positive Control Slides, Product No. 292S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

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Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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Quality